![]() PLoS ONE 13(7):Įditor: Valentin Ceña, Universidad de Castilla-La Mancha, SPAIN (2018) Image and motor behavior for monitoring tumor growth in C6 glioma model. The results of gait analysis were more sensitive than general motor analysis.Ĭitation: Souza TKF, Nucci MP, Mamani JB, da Silva HR, Fantacini DMC, de Souza LEB, et al. In addition, functional behavioral analysis displayed sensitivity to monitor tumor growth, as well as to detect early significant changes between groups, primarily in the tumor group. Our study showed a high correlation between MRI and BLI for tumor growth monitoring with complement aspects analysis in tumor volume. After 14 days of tumor induction, both behavioral tests showed significant differences between tumor and sham or control groups. The MRI showed that the mean tumor volume increased by approximately 10, 26, and 49 times according to a comparison of tumor volume on the seventh day with 14, 21, and 28 days, respectively. The tumor volume measured by magnetic resonance imaging (MRI) and quantitative bioluminescence imaging (BLI) signal showed a correlation coefficient of r = 0.96. Images and behavioral tests were evaluated at base time and at 7, 14, 21, and 28 days after induced tumor growth analysis. The sham group received implant only with culture medium without cells. The experimental group was anesthetized the C6 cells with luciferase expression that were suspended in a culture medium were implanted into the right frontoparietal cortex of the rats. ![]() Our sample includes male Wistar rats, 2 months old and weighing 250–300 g, that is categorized into three groups: control, sham, and experimental. APPLICATIONS Open-field test, Global Activity, Thygmotaxis, Circadian locomotor activity, Exploration, Holeboard test, Anxiety test, Light/Dark box test.The primary objective of this study is to monitor tumor growth by using image techniques and behavioral testing through general and specific motor activities (spontaneous movements and gait). trajectories (distance, speed, permanence time in selected zones) and then provide complementary data to those obtained using the control units. Tracking functions available through the ACTITRACK software.Optional Data Transfer software SEDACOM 2.0 (RS232/USB comunication).Can be used without any computer (independent control units with internal memory).Compact and convenient (no PCI needed, minimum cable and maintenance.).New Dark Box accessories for Dark/Light Test.Optimized configuration forin the market (1.3the smallest beams inter-space cm). ![]() Three-dimentional (XYY) evaluation using 2 IR frames.Two-dimentional (XY)andframe for providing maximum resolution accuracy. ![]()
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